Please note that we were recently made aware that two pairs of lines in our genotype files had been swapped. These were swaps that we originally identified and corrected shortly after genotyping; however, it appears that we reintroduced the swaps into the web-accessible pipeline while trying to synchronize with our colleagues at Baylor. This has now been fixed on our website and any runs on or after July 8, 2012 used the corrected genotypes. The affected pairs were lines 69/83 and 373/374.
We have also made changes to the annotations for the top_snps.txt file (updated to release 5.46). The previous annotations were outdated and contained errors. More information about this can be found under the Description tab.
We are very sorry for any inconvenience this may have caused.
Sincerely, the DGRP team.
What is DGRP?
The Drosophila Genetic Reference Panel (DGRP) is a population consisting of 192 inbred lines derived from the Raleigh, USA population. The National Institutes of Health National Human Genome Research Institute has approved the sequencing of these lines by the Baylor College of Medicine Sequencing Center, using next generation sequencing. The DGRP is a living library of common polymorphisms affecting complex traits, and a community resource for whole genome association mapping of quantitative trait loci.
This webtool allows users to perform a number of analyses aimed at providing a detailed map of genetic variants associated with any organismal phenotype of interest measured in these lines (more details under the “description” tab). This pipeline is meant to serve as a first step toward a comprehensive ‘systems genetics’ approach, provide a functional context for interpreting the phenotypes, understanding the functional basis genotype-phenotype association and potentially elucidate the genetic underpinnings that govern the interdependence of multiple phenotypes.
How do I use the DGRP Site?
Upload your data in a comma-delimited format by completing the following steps:
- Create a user account and login
This is necessary so that a notification can be sent to you when your job is complete.
- Read the description of the analysis pipeline
You can find this description using the link at the top of the page.
- Upload your data
Formatting requirements are detailed on the Example page.
- Await notification
The wait depends on demand and the size of your dataset.
- Retrieve results
Output format is described on the Example page.